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tdh [2018-09-26 09:21:55]
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tdh [2018-09-26 09:21:55]

L-threonine dehydrogenase
locus
BSU16990
pI
6.06
mw
36.84 kDa
protein length
347 aa Sequence Blast
gene length
1041 bp Sequence Blast
function
threonine utilization
product
L-threonine dehydrogenase
essential
no
ec
1.1.1.103
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.2|Utilization of amino acids] → [category|SW 2.3.2.8|Utilization of threonine/ glycine]

    • Gene

    Coordinates
    1,770,461 → 1,771,504

    The protein

    Catalyzed reaction/ biological activity

  • L-threonine + NAD+ = L-2-amino-3-oxobutanoate + NADH (according to Swiss-Prot)

    • Protein family

  • zinc-containing alcohol dehydrogenase family (according to Swiss-Prot)

    • Structure

  • [PDB|2DQ4] (from ''Thermus thermophilus'', 47% identity, 63% similarity)

    • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)

    • Expression and Regulation

    Operons

    genes
    [gene|8E64B62F15B92A2AACD68B913909100AE276D114|tdh]-[gene|1BC05699DEB3A16944FB8305F22976AED75805E8|kbl]
    description
    [Pubmed|22383849]
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    Biological materials

    Mutant

  • BKE16990 (Δ[gene|8E64B62F15B92A2AACD68B913909100AE276D114|tdh]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE16990 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTACAATCCTCCTTGAA, downstream forward: _UP4_TTAATTCCATAAAGGGGGAT
  • BKK16990 (Δ[gene|8E64B62F15B92A2AACD68B913909100AE276D114|tdh]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK16990 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTACAATCCTCCTTGAA, downstream forward: _UP4_TTAATTCCATAAAGGGGGAT